通过原位杂交将人类心脏β-肌球蛋白重链基因（MYH7）定位到14号染色体q12区。

Localization of human cardiac beta-myosin heavy chain gene (MYH7) to chromosome 14q12 by in situ hybridization.

作者信息

Qin H, Kemp J, Yip M Y, Lam-Po-Tang P R, Hoh J F, Morris B J

机构信息

Department of Physiology, University of Sydney, N.S.W., Australia.

出版信息

Cytogenet Cell Genet. 1990;54(1-2):74-6. doi: 10.1159/000132961.

DOI:10.1159/000132961

PMID:2249479

Abstract

The genes coding for each human cardiac myosin heavy chain (alpha-MHC and beta-MHC, MYH6 and MYH7, respectively) are tightly linked and the alpha-MHC gene has been assigned to chromosome 14. In order to provide a more precise regional localization, in situ hybridization experiments were carried out using a 3H-labeled probe derived from a beta-MHC genomic clone. The results demonstrated that the human cardiac MHC genes are located within the q12 band of chromosome 14.

摘要

编码每个人类心脏肌球蛋白重链的基因（分别为α-肌球蛋白重链和β-肌球蛋白重链，即MYH6和MYH7）紧密连锁，且α-肌球蛋白重链基因已被定位到14号染色体。为了提供更精确的区域定位，使用源自β-肌球蛋白重链基因组克隆的3H标记探针进行了原位杂交实验。结果表明，人类心脏肌球蛋白重链基因位于14号染色体的q12带内。