呼吸轻松测试追踪囊性纤维化的临床变化。
The ease of breathing test tracks clinical changes in cystic fibrosis.
机构信息
Children's Hospital of Pittsburgh of UPMC, Administrative Office Building, Pittsburgh, PA 15224, USA.
出版信息
J Cyst Fibros. 2012 Sep;11(5):383-6. doi: 10.1016/j.jcf.2012.03.005. Epub 2012 Apr 10.
INTRODUCTION
The EOB is a measure of dyspnea that correlates with CF pulmonary function and exercise tolerance, but has not been shown to track clinical changes.
METHODS
The EOB was administered before and after treatment for twelve episodes of exacerbations in eleven pediatric CF subjects. Each subject performed the EOB Sustained Phonation and Single Breath Counting measures before and after treatment both at rest and after exercise.
RESULTS
Phonation was significantly better pre-exercise after treatment than initially (Z=-2.20, p=0.028). Phonation post-exercise was longer at follow-up than pre- antibiotics (Z=-1.91, p=0.056). Changes in post-exercise Phonation correlated significantly with changes in FEV1 before and after treatment (R=0.66, p=0.020).
CONCLUSIONS
The EOB Sustained Phonation is a validated tool for tracking improvement of pediatric CF patients after antibiotic therapy and has potential as a research tool to gauge efficacy of new therapies.
简介
EOB 是一种呼吸困难的衡量标准，与 CF 肺功能和运动耐量相关，但尚未显示可跟踪临床变化。
方法
在 11 名儿科 CF 患者的 12 次加重期治疗前后进行了 EOB 测试。每个患者在治疗前后均在休息和运动后进行 EOB 持续发音和单次计数测量。
结果
治疗前运动后的发音明显优于初始时（Z=-2.20，p=0.028）。与抗生素治疗前相比，运动后发音时间更长（Z=-1.91，p=0.056）。治疗前后运动后发音的变化与 FEV1 的变化显著相关（R=0.66，p=0.020）。
结论
EOB 持续发音是一种经过验证的工具，可用于跟踪儿科 CF 患者在抗生素治疗后的改善情况，并且具有作为评估新疗法疗效的研究工具的潜力。
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