住院囊性纤维化儿童和青少年改良穿梭试验的表现

Modified shuttle test performance in hospitalized children and adolescents with cystic fibrosis.

作者信息

Cox Narelle S, Follett Jennifer, McKay Karen O

机构信息

Department of Physiotherapy, The Children's Hospital at Westmead, Westmead NSW, Australia.

出版信息

J Cyst Fibros. 2006 Aug;5(3):165-70. doi: 10.1016/j.jcf.2006.02.004. Epub 2006 May 5.

DOI:10.1016/j.jcf.2006.02.004

PMID:16679070

Abstract

BACKGROUND

The Modified Shuttle Test (MST) is a valid and sensitive measure of exercise capacity in adult CF patients. Recently, its validity in children has been demonstrated. The aim of this study was to demonstrate the utility of the MST as a measure of responsiveness to hospitalisation for i.v. antibiotic and supportive therapy in children and adolescents with CF.

METHODS

28 children and adolescents (40 admissions) performed a MST and lung function within 48 h of admission and discharge to hospital for administration of intravenous antibiotics. Mean age was 12.7 years and antibiotic therapy length was 14.7 days.

RESULTS

Upon admission, the mean (S.D.) FEV(1) was 63 (19)% predicted, FVC was 80 (18)% predicted, FEF(25-75) 43 (29)% predicted and MST distance 718 (232) m. FEV(1) increased by 15% (p<or=0.001), FVC by 13% (p<or=0.001), FEF(25-75) by 39% (p<or=0.001) and MST distance by 102 m (p<or=0.001). The percentage improvement in MST distance at 18% (p<or=0.001) was similar to that for FEV(1), but could not be predicted by the change in FEV(1).

CONCLUSION

This study demonstrated the utility of the MST to assess the effect of hospitalisation for i.v. antibiotic and supportive therapy in children and adolescents with CF.

摘要

背景

改良往返跑试验（MST）是评估成年囊性纤维化（CF）患者运动能力的有效且敏感的指标。最近，已证实其在儿童中的有效性。本研究的目的是证明MST作为衡量CF儿童和青少年静脉注射抗生素及支持性治疗住院反应性的指标的实用性。

方法

28名儿童和青少年（40次住院）在入院和出院后48小时内进行了MST和肺功能测试，以便接受静脉抗生素治疗。平均年龄为12.7岁，抗生素治疗时长为14.7天。

结果

入院时，平均（标准差）第1秒用力呼气容积（FEV₁）为预测值的63%（19%），用力肺活量（FVC）为预测值的80%（18%），25%-75%用力呼气流量（FEF₂₅₋₇₅）为预测值的43%（29%），MST距离为718米（232米）。FEV₁增加了15%（p≤0.001），FVC增加了13%（p≤0.001），FEF₂₅₋₇₅增加了39%（p≤0.001），MST距离增加了102米（p≤0.001）。MST距离改善百分比为18%（p≤0.001），与FEV₁相似，但无法通过FEV₁的变化预测。