State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
J Surg Res. 2012 Nov;178(1):255-63. doi: 10.1016/j.jss.2012.02.002. Epub 2012 Apr 2.
Portal vein embolization (PVE) has become a standard preoperative procedure to promote hypertrophy of the future remnant liver to reduce postoperative liver failure. Whether PVE accelerates tumor growth is still controversial. We developed a left PVE procedure and investigated its effect on liver hypertrophy and tumor growth in a rabbit liver tumor model.
VX2 tumors were implanted in both the external left and right middle lobe (the bilateral group) or in the external left lobe only (the unilateral group) of rabbit liver. Both groups were further divided into a PVE or a sham/control group. Tumor volume and tumor growth rate as volume relative increase were determined by ultrasound. Liver volume-to-body weight index, an index for liver volume, was compared. Serum HGF was measured by ELISA.
In the bilateral PVE group, tumor volume and relative increase value in the nonembolized lobe were significantly (71% and 65%, respectively) greater than those in the control group at 5 d post-PVE. In the unilateral PVE group, liver volume-to-body weight index of the nonembolized lobes was significantly increased by 17%. Increase of serum HGF level after PVE was correlated well with both tumor growth and liver hypertrophy.
Left PVE promoted both the growth of implanted tumors and liver hypertrophy in the nonembolized liver, in which serum HGF might play an important role.
门静脉栓塞术（PVE）已成为促进剩余肝脏肥大以减少术后肝功能衰竭的标准术前程序。PVE 是否会加速肿瘤生长仍存在争议。我们开发了一种左 PVE 程序，并在兔肝肿瘤模型中研究了其对肝肥大和肿瘤生长的影响。
VX2 肿瘤分别植入兔肝的外部左、右中叶（双侧组）或仅外部左叶（单侧组）。两组均进一步分为 PVE 或假手术/对照组。通过超声确定肿瘤体积和肿瘤生长率（以体积相对增加表示）。比较肝体积与体重指数，即肝体积指标。通过 ELISA 测量血清 HGF。
在双侧 PVE 组中，PVE 后 5 天，非栓塞侧的肿瘤体积和相对增加值分别显著（分别为 71%和 65%）大于对照组。在单侧 PVE 组中，非栓塞侧的肝体积与体重指数增加了 17%。PVE 后血清 HGF 水平的升高与肿瘤生长和肝肥大均密切相关。
左 PVE 促进了植入肿瘤的生长和非栓塞肝的肥大，其中血清 HGF 可能发挥重要作用。
