Department of Anesthesiology, Shioya Hospital, International University of Health and Welfare, Tochigi 329-2145, Japan.
J Clin Anesth. 2012 May;24(3):207-11. doi: 10.1016/j.jclinane.2011.07.015. Epub 2012 Apr 9.
To investigate changes in stroke volume variation (SVV) by both induced hypertension (pressor test) and hypotension (depressor test), and also by induced hypotensive anesthesia in patients with good cardiac function.
Prospective, controlled clinical study.
University hospital.
31 ASA physical status 1 and 2 patients, aged 39-62 years, who were scheduled for elective surgery.
We conducted three studies: a pressor test study, a depressor test study, and an induced hypotensive anesthesia study. In the pressor test, patients received a bolus of phenylephrine 0.001 mg/kg to increase systolic arterial pressure (SAP) by 30% to 40% compared with baseline. In the depressor test, patients received a bolus of nitroglycerine 0.005 mg/kg to decrease SAP by 30% to 40% compared with baseline. In the induced hypotensive anesthesia test, patients received intravenous (IV) nitroglycerine continuously until mean arterial pressure (MAP) was reduced to 60-70 mmHg.
When arterial pressure reached the target pressure for each study type, SVV and other parameters were recorded.
Induced hypertension (pressor test) decreased SVV, while induced hypotension (depressor test) and induced hypotensive anesthesia increased SVV.
SVV does not misinterpret preload dependency assessment of patients receiving medications to increase or to lower blood pressure.
研究心功能良好的患者在接受升压（升压试验）、降压（降压试验）和降压麻醉诱导时，每搏量变异度（SVV）的变化。
前瞻性、对照临床研究。
大学医院。
31 名 ASA 身体状况 1 级和 2 级患者，年龄 39-62 岁，择期手术。
我们进行了三项研究：升压试验研究、降压试验研究和降压麻醉诱导研究。在升压试验中，患者接受苯肾上腺素 0.001mg/kg 推注，使收缩压（SAP）较基础值升高 30%至 40%。在降压试验中，患者接受硝酸甘油 0.005mg/kg 推注，使 SAP 较基础值降低 30%至 40%。在降压麻醉诱导试验中，患者静脉持续输注硝酸甘油，直至平均动脉压（MAP）降至 60-70mmHg。
当动脉压达到每种研究类型的目标压力时，记录 SVV 和其他参数。
诱导性高血压（升压试验）降低了 SVV，而诱导性低血压（降压试验）和降压麻醉诱导增加了 SVV。
SVV 不会错误地解释接受药物升压或降压的患者的前负荷依赖性评估。
