Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
J Psychopharmacol. 2012 Oct;26(10):1317-32. doi: 10.1177/0269881112441865. Epub 2012 Apr 9.
Recently, a novel paradigm has been designed to assess social investigative behaviour in pairs of Sprague-Dawley rats, which involves physical separation whilst ensuring they are able to maintain contact through other social cues. We have modified this set-up in order to assess not just social behaviour but also locomotor activity of the rats. Results showed that the MK-801- (0.3 mg/kg) treated rats displayed reduced social investigative behaviour, hyperactivity as well as reduced attention span. Pretreatment with the phytocannabinoid cannabidiol (3 mg/kg) not only normalised social investigative behaviour but increased it beyond control levels. Pretreatment with clozapine (1, 3 mg/kg) also normalised social investigative behaviour. Both cannabidiol and clozapine inhibited MK-801-induced hyperactivity. However, there were no effects of pretreatment on impairments to attention span. Our findings reinforce several aspects of the validity of the MK-801-induced model of social withdrawal and hyperactivity and also support the use of this novel set-up for further investigations to assess the antipsychotic potential of novel compounds.
最近，设计了一种新的范式来评估 pair 对 Sprague-Dawley 大鼠的社会探究行为，该范式涉及物理分离，同时确保它们能够通过其他社会线索保持联系。我们修改了这个设置，以便不仅评估大鼠的社会行为，还评估它们的运动活性。结果表明，MK-801（0.3 mg/kg）处理的大鼠表现出社交探究行为减少、多动以及注意力持续时间减少。用植物大麻素大麻二酚（3 mg/kg）预处理不仅使社交探究行为正常化，而且使其超过对照水平。氯氮平（1、3 mg/kg）预处理也使社交探究行为正常化。大麻二酚和氯氮平均抑制 MK-801 诱导的多动。然而，预处理对注意力持续时间的损害没有影响。我们的发现强化了 MK-801 诱导的社会回避和多动模型的几个方面的有效性，并支持使用这种新设置进行进一步的研究，以评估新型化合物的抗精神病潜力。
