Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo-ku, Kyoto 606-8501, Japan.
J Biochem. 2012 May;151(5):477-81. doi: 10.1093/jb/mvs035. Epub 2012 Apr 9.
Although our understanding of epithelial cancer cells has advanced significantly, our understanding of the cancer microenvironment is still fragmentary. In contrast to our intuitive impression that our body always suppresses cancer growth, recent pieces of evidence show that cancer often exploits our body reactions to expand, invade local tissues and metastasize to distant organs. Accordingly, investigations of such body reactions in the tumour microenvironment should help us to design novel therapeutic strategies that can be combined with the traditional therapeutics targeted at the cancer cells themselves. In this article, I am going to review our recent efforts in search of novel therapeutic strategies against colon cancer using mouse models.
尽管我们对上皮癌细胞的认识已经有了显著的提高，但我们对癌症微环境的理解仍然是零碎的。与我们直观的印象相反，即我们的身体总是抑制癌症的生长，最近的一些证据表明，癌症经常利用我们身体的反应来扩张、侵犯局部组织并转移到远处的器官。因此，对肿瘤微环境中这种身体反应的研究应该有助于我们设计新的治疗策略，这些策略可以与针对癌细胞本身的传统治疗相结合。在本文中，我将回顾我们最近使用小鼠模型寻找针对结肠癌的新治疗策略的努力。
