Perera V Y, Corbel M J
Division of Bacteriology, National Institute of Biological Standards and Control, Potters Bar, Herts, England.
Epidemiol Infect. 1990 Dec;105(3):457-68. doi: 10.1017/s095026880004807x.
Examination of a selection of serum samples from adults from two regions of England showed that 50% of men in the 16-24 years and over 55 years age groups had high titres of antibody to diphtheria toxin (DT). In contrast, only 11% of women aged 16 to over 55 years had high titres of antibody to DT. All human antisera with high anti-DT titres reacted with a synthetic peptide (SP) corresponding to the amino acids 141-157 of DT fragment A, with sera from men aged 35 to over 55 years showing the highest titres. High antibody titres to fragment A paralleled those to SP in both sexes. Titres of antibody to DT fragment B were highest in individuals with high titres to DT. In sera from both sexes immunoglobulin G1 was the predominant subclass reactive with all three antigens. However, both IgG1 and IgG4 and to a lesser extent IgG2 and IgG3 were present in immunoglobulin concentrates.
对来自英格兰两个地区的成年人的一系列血清样本进行检测发现，16 - 24岁和55岁以上年龄组的男性中有50%对白喉毒素（DT）具有高滴度抗体。相比之下，16岁至55岁以上的女性中只有11%对白喉毒素具有高滴度抗体。所有抗DT高滴度的人抗血清都与对应于DT片段A氨基酸141 - 157的合成肽（SP）发生反应，35岁至55岁以上男性的血清显示出最高滴度。两性中针对片段A的高抗体滴度与针对SP的滴度平行。针对DT片段B的抗体滴度在抗DT高滴度的个体中最高。在两性血清中，免疫球蛋白G1是与所有三种抗原反应的主要亚类。然而，免疫球蛋白浓缩物中同时存在IgG1和IgG4，以及程度较轻的IgG2和IgG3。
