Yonekura Syuji, Okamoto Yoshitaka, Shimojo Naoki, Yamamoto Heizaburo, Sakurai Daiju, Horiguchi Shigetoshi, Hanazawa Toyoyuki, Inoue Yuzaburo, Arima Takayasu, Tomiita Minako, Kohno Yoichi
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Japan.
Acta Otolaryngol. 2012 Sep;132(9):981-7. doi: 10.3109/00016489.2012.664782. Epub 2012 Apr 12.
This preliminary prospective study suggests that background factors may differ among allergic diseases. The beneficial interventions for reducing development of allergic rhinitis (AR) are also effective for the prevention of subsequent onset of bronchial asthma (BA).
To determine the risk factors associated with onset of AR in atopic children in a prospective study.
All patients with atopic dermatitis (AD) or food allergy with or without BA who visited the Pediatric Unit of Chiba University Hospital from 2005 to 2006 were enrolled in the study and received allergy examinations every 3-6 months.
A total of 100 patients were followed up for more than 2 years. Among the 60 patients without BA at entry to the study, 12 developed BA during the follow-up period. Development of AR preceded BA in 10 of the 12 patients (83.3%). In the background factors at the entry, positive sensitization to house dust mite (HDM) was significantly related to development of BA. Among the 48 patients without AR, 20 developed AR. High titers of serum HDM-specific IgE and high eosinophil counts in blood, and detection of eosinophils in nasal smears at the entry were significantly related to development of AR.
这项初步前瞻性研究表明，过敏性疾病的背景因素可能存在差异。减少过敏性鼻炎（AR）发生的有益干预措施对预防随后发生支气管哮喘（BA）也有效。
在一项前瞻性研究中确定特应性儿童AR发病的相关危险因素。
2005年至2006年期间就诊于千叶大学医院儿科病房的所有患有特应性皮炎（AD）或食物过敏且伴有或不伴有BA的患者均纳入本研究，并每3 - 6个月接受一次过敏检查。
共对100例患者进行了2年以上的随访。在研究开始时无BA的60例患者中，有12例在随访期间发生了BA。12例患者中有10例（83.3%）在发生BA之前先出现了AR。在研究开始时的背景因素中，对屋尘螨（HDM）的阳性致敏与BA的发生显著相关。在48例无AR的患者中，有20例发生了AR。研究开始时血清HDM特异性IgE高滴度、血液中嗜酸性粒细胞计数高以及鼻涂片检测到嗜酸性粒细胞与AR的发生显著相关。
