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1q21 amplification with additional genetic abnormalities but not isolated 1q21 gain is a negative prognostic factor in newly diagnosed patients with multiple myeloma treated with thalidomide-based regimens.

作者信息

Grzasko Norbert, Hus Marek, Chocholska Sylwia, Pluta Andrzej, Hajek Roman, Dmoszynska Anna

出版信息

Leuk Lymphoma. 2012 Dec;53(12):2500-3. doi: 10.3109/10428194.2012.684349. Epub 2012 May 22.

DOI:10.3109/10428194.2012.684349
PMID:22497640
Abstract
摘要

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1
1q21 amplification with additional genetic abnormalities but not isolated 1q21 gain is a negative prognostic factor in newly diagnosed patients with multiple myeloma treated with thalidomide-based regimens.伴有其他基因异常的1q21扩增而非孤立性1q21获得是接受沙利度胺方案治疗的新诊断多发性骨髓瘤患者的不良预后因素。
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2
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引用本文的文献

1
Chromosome 1q21 Aberrations Are Poor Prognostic Factors for Newly Diagnosed Multiple Myeloma Patients.1q21 染色体异常是多发性骨髓瘤初诊患者的不良预后因素。
J Clin Lab Anal. 2024 Sep;38(17-18):e25072. doi: 10.1002/jcla.25072. Epub 2024 Sep 12.
2
Amp 1q21 is more predictable with dismal survival than gain 1q21 of newly diagnosed multiple myeloma in real-world analysis.在真实世界分析中，与新诊断多发性骨髓瘤的 1q21 增益相比，1q21 扩增具有更差的预后。
J Clin Lab Anal. 2022 Jul;36(7):e24375. doi: 10.1002/jcla.24375. Epub 2022 Mar 30.
3
Gain/Amplification of Chromosome Arm 1q21 in Multiple Myeloma.
多发性骨髓瘤中1q21染色体臂的获得/扩增
Cancers (Basel). 2021 Jan 12;13(2):256. doi: 10.3390/cancers13020256.
4
Observation on frequency & clinico-pathological significance of various cytogenetic risk groups in multiple myeloma: an experience from India.多发性骨髓瘤中各种细胞遗传学风险组的频率及临床病理意义观察：来自印度的经验
Indian J Med Res. 2016 Oct;144(4):536-543. doi: 10.4103/0971-5916.200890.