染色体不稳定性：纺锤体检验点之外的 Mad2
Chromosomal Instability: Mad2 beyond the spindle checkpoint.
机构信息
Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Curr Biol. 2012 Apr 10;22(7):R233-5. doi: 10.1016/j.cub.2012.02.059.
PMID:22497940
Abstract
What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.
摘要
哪些具体缺陷会导致癌细胞的染色体不稳定？有丝分裂检验点蛋白 Mad2 的过表达会引发染色体错误分离，但令人惊讶的是，Mad2 通过对微管动力学的先前未知影响发挥了这种作用。
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