Department f Neurosurgery, University Hospital, Heinrich-Heine-University, Düsseldorf, MoorenstraBe 5, D-40225, Düsseldorf, Germany.
Rev Neurosci. 2012 Feb 29;23(2):179-90. doi: 10.1515/revneuro-2011-0070.
Why mediate P-/Q-type and not N-type Ca2+ channels in cerebellar inhibitory interneurons? Neurotransmitter release relies most on P-/Q- and N-type Ca2+ channels in the vast majority of neurons, although all types of voltage-gated Ca2+ channels are competent in initiating exocytosis. Up to date, it remains unclear why a particular Ca2+ channel type mediates neurotransmission in certain axon terminals and another type of Ca2+ channel evokes neurotransmission in axon terminals of another region. Therefore, the present review analyzes the diversity of presynaptic Ca2+ channels displaying different synaptic properties and focuses on an analysis of distribution and function of presynaptic voltage-gated Ca2+ channels, as well as on developmental changes.
为什么要调节小脑抑制性中间神经元中的 P-/Q-型而非 N-型 Ca2+通道？在绝大多数神经元中，神经递质释放主要依赖于 P-/Q-和 N-型 Ca2+通道，尽管所有类型的电压门控 Ca2+通道都有能力引发胞吐作用。迄今为止，尚不清楚为什么特定的 Ca2+通道类型在某些轴突末梢介导神经递质传递，而另一种 Ca2+通道在另一个区域的轴突末梢引发神经递质传递。因此，本综述分析了具有不同突触特性的突触前 Ca2+通道的多样性，并重点分析了突触前电压门控 Ca2+通道的分布和功能以及发育变化。
