Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Neuron. 2012 Apr 12;74(1):3-5. doi: 10.1016/j.neuron.2012.03.012.
Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of Neuron, Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.
轴突靶源性 BMP 和神经营养因子信号都被认为可以调节神经元的基因表达、分化和轴突生长。在本期《神经元》杂志中,Ji 和 Jaffrey(2012)发现 BMP 信号内体依赖于 BDNF 诱导的轴突合成 SMADs,从而逆行调节发育中的三叉神经神经元中的转录,为整合这两种靶源性信号提供了一种机制。