Davidson T, Tobin A M, Payne A P
Department of Anatomy, University of Glasgow, UK.
J Reprod Fertil. 1990 Nov;90(2):619-23. doi: 10.1530/jrf.0.0900619.
Female Albino Swiss rats were exposed to 5 alpha-dihydrotestosterone benzoate (DHTB) for the last 4 days of gestation, or for 4 days after birth, or both. Post-natal DHTB exposure (as well as pre-plus post-natal exposure) resulted in a 2-3-fold increase in the number of motor neurones forming the spinal nucleus of bulbocavernosus (SNB); numbers were intermediate between those found in normal females (approximately 40) and males (approximately 200). These DHTB-treated groups also possessed perineal muscles which were approximately 25% of the weight of those in normal males. Transverse sections of one of the muscles (levator ani) showed that it had approximately half the muscle fibres of normal males. Females exposed prenatally to DHTB showed a small (but significant) rise in SNB numbers, but had no recognizable perineal muscles.
在妊娠的最后4天、出生后的4天或这两个阶段，对白化瑞士雌性大鼠暴露于5α - 二氢睾酮苯甲酸酯（DHTB）。产后暴露于DHTB（以及产前加产后暴露）导致构成球海绵体肌脊髓核（SNB）的运动神经元数量增加2至3倍；其数量介于正常雌性大鼠（约40个）和雄性大鼠（约200个）之间。这些经DHTB处理的组也拥有会阴肌，其重量约为正常雄性大鼠会阴肌重量的25%。其中一块肌肉（肛提肌）的横切面显示，其肌纤维数量约为正常雄性大鼠的一半。产前暴露于DHTB的雌性大鼠SNB数量有小幅（但显著）增加，但没有可识别的会阴肌。
