Department of Cardiothoracic Surgery, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, United Kingdom.
Heart Lung Circ. 2012 Aug;21(8):455-62. doi: 10.1016/j.hlc.2012.03.011. Epub 2012 Apr 11.
Increasing numbers of patients are undergoing cardiac surgery on dual antiplatelet therapy following previous percutaneous coronary intervention. The dilemma of stopping antiplatelet therapy prior to surgery with risk of stent thrombosis, versus continuation and risk of post-operative bleeding has received much debate. Currently, an accurate and standardised method of predicting antiplatelet drug efficacy has not yet been determined and significant inter-individual variance has been shown. This review focuses on the most widely used laboratory and point of care assays currently available to measure platelet function and recent published data evaluating these methods. Further studies may enable predictive values to be defined, to guide the practicing clinician in balancing the risk of thrombosis versus haemorrhage.
越来越多的患者在先前经皮冠状动脉介入治疗后接受双联抗血小板治疗下进行心脏手术。在停止抗血小板治疗以降低支架血栓形成的风险与继续治疗并增加术后出血风险之间存在争议。目前，尚未确定准确且标准化的预测抗血小板药物疗效的方法，且个体间差异显著。这篇综述重点介绍了目前用于测量血小板功能的最广泛使用的实验室和即时检测检测方法，以及评估这些方法的最新发表数据。进一步的研究可能使预测值得以确定，从而为临床医生平衡血栓形成与出血风险提供指导。
