Mitsuhashi N, Takahashi M, Okazaki A, Niibe H
Dept. of Radiology, Gunma Univ. School of Med.
Gan No Rinsho. 1990 Oct;36(13):2272-7.
This article reports on attempt to characterize the interactions of radiation and BRMs in the treatment of malignant tumor on the basis of our some experimental results. BRMs have a high possibility to enhance radiation effects on tumor cells with in a radiation field and bring some benefits to host tumor immune system with minimizing deleterious effects of irradiation to the immune responses. But it is very difficult to determine the rational design of administration of BRMs to induce the most effective interactions on relevant immune system and other host responses in the combination with radiotherapy. We should make it clear how radiation can be useful to potentiate the tumor antigenecity or antitumor immune responses.
本文基于我们的一些实验结果，报道了在恶性肿瘤治疗中对辐射与生物反应调节剂（BRMs）相互作用进行表征的尝试。生物反应调节剂极有可能增强辐射对辐射场内肿瘤细胞的作用，并在将辐射对免疫反应的有害影响降至最低的同时，给宿主肿瘤免疫系统带来一些益处。但是，要确定生物反应调节剂的合理给药方案，以在与放疗联合时对相关免疫系统和其他宿主反应诱导最有效的相互作用，是非常困难的。我们应该弄清楚辐射如何能够有助于增强肿瘤抗原性或抗肿瘤免疫反应。
