Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
Int J Gynaecol Obstet. 2012 Jul;118(1):15-7. doi: 10.1016/j.ijgo.2012.01.026. Epub 2012 Apr 13.
To investigate factors associated with latent syphilis and pregnancy outcome among women with latent syphilis.
A retrospective population-based study was conducted to compare all pregnancies among women with and without latent syphilis at Soroka University Medical Center, Be'er-Sheva, Israel, between 1988 and 2010. Stratified analysis using a multiple logistic regression model was performed to control for confounders.
Of the 219656 deliveries during the study period, 159 (0.1%) involved women with latent syphilis. Multivariate analysis with backward elimination revealed the following conditions to be significantly associated with latent syphilis: fetal growth restriction (odds ratio [OR] 2.20; 95% confidence interval [CI], 1.07-4.49; P=0.03); drug abuse (OR 9.95; 95% CI, 1.31-75.46; P=0.02); tobacco use (OR 3.35; 95% CI, 1.74-6.45; P<0.05); and Jewish (vs Bedouin) ethnicity (OR 4.05; 95% CI, 2.65-6.20; P<0.05).
Women with latent syphilis are at risk for adverse maternal and perinatal outcomes, including fetal growth restriction. Careful surveillance of these high-risk pregnancies should be considered.
探讨潜伏梅毒女性患者中与潜伏梅毒相关的因素及其对妊娠结局的影响。
采用回顾性人群基础研究方法，比较 1988 年至 2010 年期间以色列贝尔谢巴索拉卡大学医学中心所有潜伏梅毒女性患者与无潜伏梅毒女性患者的妊娠情况。采用多变量逻辑回归模型进行分层分析，以控制混杂因素。
在研究期间的 219656 次分娩中，有 159 例（0.1%）涉及潜伏梅毒女性患者。采用向后消除法进行多变量分析，结果显示以下情况与潜伏梅毒显著相关：胎儿生长受限（比值比 [OR] 2.20；95%置信区间 [CI]，1.07-4.49；P=0.03）；药物滥用（OR 9.95；95% CI，1.31-75.46；P=0.02）；吸烟（OR 3.35；95% CI，1.74-6.45；P<0.05）；以及犹太（vs 贝都因）种族（OR 4.05；95% CI，2.65-6.20；P<0.05）。
潜伏梅毒女性患者存在发生不良母婴和围产期结局的风险，包括胎儿生长受限。应考虑对这些高危妊娠进行密切监测。
