Michael Smith Laboratories and the Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Curr Opin Plant Biol. 2012 Aug;15(4):392-9. doi: 10.1016/j.pbi.2012.03.014. Epub 2012 Apr 13.
As a common protein modification, ubiquitination is used for regulating the fate of protein targets, notably in terms of stability. In recent years, it has emerged to play key roles in the regulation of plant defense responses. Given its flexibility and critical roles in signaling, primarily in the control of protein turnover, ubiquitination is probably targeting many major immune regulators for modification or degradation. In this review, we summarize the latest findings on how different components of the ubiquitination pathway are involved in NB-LRR R protein-mediated immunity.
泛素化作为一种常见的蛋白修饰方式，用于调控蛋白靶标的命运，尤其是在稳定性方面。近年来，它在植物防御反应的调控中发挥着关键作用。鉴于其在信号转导中的灵活性和关键作用，主要是在控制蛋白周转方面，泛素化可能针对许多主要的免疫调节剂进行修饰或降解。在这篇综述中，我们总结了泛素化途径的不同组成部分如何参与 NB-LRR R 蛋白介导的免疫的最新发现。
