Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl-von-Linne Weg 10, 50829 Cologne, Germany.
Curr Opin Plant Biol. 2012 Aug;15(4):385-91. doi: 10.1016/j.pbi.2012.03.015. Epub 2012 Apr 12.
In plants, a large polymorphic family of intracellular NB-LRR receptors lies at the heart of robust resistance to diverse pathogens and mechanisms by which these versatile molecular switches operate in effector-triggered immunity are beginning to emerge. We outline recent advances in our understanding of NB-LRR receptor signaling leading to disease resistance. Themes covered are (i) NB-LRR molecular constraining forces and their intimate relationship with receptor activation in different parts of the cell, (ii) cooperativity between NB-LRR proteins and the formation of higher order NB-LRR signaling complexes, and (iii) the spatial separation of different resistance branches within cells. Finally, we examine evidence for dynamic signaling across cell compartments in coordinating diverse immune outputs.
在植物中，一大类细胞内的 NB-LRR 受体多态家族是对多种病原体产生强大抗性的核心，这些多功能分子开关在效应子触发免疫中发挥作用的机制也开始显现。我们概述了我们对 NB-LRR 受体信号转导导致抗病性的理解的最新进展。涵盖的主题包括：（i）NB-LRR 分子约束因素及其与细胞不同部位受体激活的密切关系；（ii）NB-LRR 蛋白之间的协同作用以及更高阶 NB-LRR 信号复合物的形成；（iii）细胞内不同抗性分支的空间分离。最后，我们研究了证据表明在协调不同免疫反应中细胞区室之间的动态信号转导。
