Ishikawa I, Shikura N, Shinoda A, Fukuda Y, Tsugawa R, Suzuki K
Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan.
Nihon Jinzo Gakkai Shi. 1990 Aug;32(8):929-32.
The kidney volume after transplantation was compared in two groups, one treated by conventional immunosuppression and the other receiving small amounts of ciclosporin (CsA) together with azathioprine and steroid (the so-called triple therapy). Fourteen pairs of donors and recipients were investigated in each group. The kidney volume was measured, using computed tomography (CT scan), before and after transplantation in the donors and after transplantation in the recipients during the allograft rejection-free period. The graft volume at 2-3 months after transplantation was smaller (215.9 +/- 30.9 ml, mean +/- SD) in patients who received small amounts of ciclosporin A (CsA) together with azathioprine and steroid than that (270.9 +/- 75.0 ml) in those treated by conventional immunosuppression. The remaining kidney in the donor after transplantation underwent a similar increase in volume in the conventional and triple therapy groups. It is suggested that even a small amount of CsA can significantly limit the compensatory renal growth.
对两组移植后的肾脏体积进行了比较，一组采用传统免疫抑制治疗，另一组接受小剂量环孢素（CsA）联合硫唑嘌呤和类固醇（即所谓的三联疗法）。每组研究了14对供体和受体。在移植前和移植后，使用计算机断层扫描（CT扫描）测量供体的肾脏体积，并在同种异体移植无排斥期测量受体移植后的肾脏体积。接受小剂量环孢素A（CsA）联合硫唑嘌呤和类固醇治疗的患者，移植后2 - 3个月时的移植肾体积（215.9 +/- 30.9 ml，平均值 +/- 标准差）小于接受传统免疫抑制治疗患者的移植肾体积（270.9 +/- 75.0 ml）。移植后供体的剩余肾脏在传统治疗组和三联疗法组中体积增加情况相似。提示即使是小剂量的CsA也能显著限制代偿性肾生长。
