Center for Basic and Translational Obesity Research, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
J Surg Res. 2013 Jan;179(1):e91-8. doi: 10.1016/j.jss.2012.02.036. Epub 2012 Mar 10.
Gastrointestinal weight loss surgery, especially Roux-en-Y gastric bypass (RYGB), is the most effective treatment for severe obesity. RYGB is associated with a remarkable decrease in the rate of death from obesity-related complications, such as diabetes mellitus, coronary artery disease, and cancer. Dissecting the mechanisms of RYGB effects could augment our understanding about the pathogenesis of obesity and its complications.
In this study, we describe in detail a mouse model of RYGB that closely reproduces the surgical steps of the human procedure.
We show that RYGB in mice has the same effects as in human patients, proving the high translational validity of this model system. We present an intraoperative video to facilitate the widespread use of this complex and difficult method.
The study of the mechanisms of RYGB using this model system can greatly facilitate our understanding about the effects of RYGB in human patients. The reverse engineering of the physiological mechanisms of RYGB could lead to discovery of new, effective, and less invasive treatments.
胃肠道减重手术，特别是 Roux-en-Y 胃旁路术（RYGB），是治疗严重肥胖症最有效的方法。RYGB 与肥胖相关并发症（如糖尿病、冠心病和癌症）死亡率的显著下降有关。剖析 RYGB 效果的机制可以增进我们对肥胖及其并发症发病机制的理解。
在本研究中，我们详细描述了一种模拟人类手术步骤的 RYGB 小鼠模型。
我们证明 RYGB 在小鼠中的效果与人类患者相同，证明了该模型系统具有很高的转化有效性。我们提供了一段术中视频，以促进这种复杂且困难方法的广泛应用。
使用该模型系统研究 RYGB 的机制可以极大地促进我们对 RYGB 对人类患者影响的理解。对 RYGB 生理机制的逆向工程可能会发现新的、有效且微创的治疗方法。
