神经内分泌肿瘤中 Geminin 的表达：恶性肿瘤的可能新标志物。

Geminin expression in pancreatic neuroendocrine tumors: possible new marker of malignancy.

机构信息

Division of Digestive Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

出版信息

Pancreas. 2012 May;41(4):512-7. doi: 10.1097/MPA.0b013e31823ca3e0.

DOI:10.1097/MPA.0b013e31823ca3e0

PMID:22504377

Abstract

OBJECTIVES

We evaluated geminin labeling index (LI) as a new prognostic indicator of pancreatic neuroendocrine tumor.

METHODS

Twenty-seven patients who underwent surgery were retrospectively referred. Labeling indices for geminin and Ki-67 were calculated and compared with clinicopathologic factors. Then, the concordance of positivity between 2 LIs was evaluated using the color difference quotation.

RESULTS

The median (range) of LIs for geminin and Ki-67 was 1.0% (0.05%-14.9%) and 1.5% (0.02%-8.8%), respectively. When the high LI was defined as more than 2.0% according to the receiver operating characteristic curves determining the metastasis, both geminin LI (hazard ratio [HR], 31.382; 95% confidence interval [CI], 3.177-309.99; P = 0.003) and Ki-67 LI (HR, 6.182; 95% CI, 1.221-31.298; P = 0.028) were significant risk factors of recurrence in the univariate analysis. The Kaplan-Meier curves consistently exhibited the superiority of geminin LI (log rank, P < 0.001) to Ki-67 LI (log rank, P = 0.041) in predicting the disease-free survival. In the color difference quotation, the median ΔE of geminin stain (16.12; range, 5.8-41.9) was significantly larger than that of Ki-67 stain (13.17; range, 3.4-37.9).

CONCLUSIONS

The geminin LI was suggested to be more closely correlated with outcome and had more consistent positivity than the Ki-67 LI.

摘要

目的

我们评估了增殖细胞核抗原（geminin）标记指数（LI）作为胰腺神经内分泌肿瘤的新的预后指标。

方法

回顾性分析了 27 例接受手术的患者。计算了 geminin 和 Ki-67 的标记指数，并与临床病理因素进行了比较。然后，使用色差报价评估了 2 个 LI 的阳性一致性。

结果

geminin 和 Ki-67 的 LI 中位数（范围）分别为 1.0%（0.05%-14.9%）和 1.5%（0.02%-8.8%）。当根据确定转移的受试者工作特征曲线将高 LI 定义为超过 2.0%时，geminin LI（危险比[HR]，31.382；95%置信区间[CI]，3.177-309.99；P=0.003）和 Ki-67 LI（HR，6.182；95%CI，1.221-31.298；P=0.028）在单因素分析中均为复发的显著危险因素。Kaplan-Meier 曲线一致显示 geminin LI（对数秩，P<0.001）优于 Ki-67 LI（对数秩，P=0.041）在预测无病生存方面的优越性。在色差报价中，geminin 染色的中位数ΔE（16.12；范围，5.8-41.9）明显大于 Ki-67 染色的中位数ΔE（13.17；范围，3.4-37.9）。