MDR1 C3435 多态性对肾移植受者他克莫司药代动力学影响的荟萃分析。
Meta-analysis of the effect of MDR1 C3435 polymorphism on tacrolimus pharmacokinetics in renal transplant recipients.
机构信息
Department of Clinical Immunological Laboratory, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
出版信息
Transpl Immunol. 2012 Aug;27(1):12-8. doi: 10.1016/j.trim.2012.03.006. Epub 2012 Apr 5.
BACKGROUND
The published data revealed conflicting results of the polymorphism of MDR1 exon 26 SNP C3435T on the pharmacokinetics of tacrolimus in different post transplant times; thus, the aim was to perform a meta-analysis of different post transplant times to investigate the influence of SNP C3435T on the tacrolimus pharmacokinetics.
METHODS
A literature search was conducted to locate the relevant papers by using the PUBMED and EMBASE electronic source until 2011. The pharmacokinetic parameters, including dose administration, concentration and concentration to dose ratio were extracted and a meta-analysis was performed by using STATA10.0.
RESULTS
A total of 13 papers concerning 1327 individuals were included in the meta-analysis. The overall results showed SNP C3435T could influence the pharmacokinetic parameters in different post transplant times, the subjects with CC genotype had lower concentration dose ratio and need higher tacrolimus dose than the CT and TT genotype.
CONCLUSIONS
Our meta-analysis of available studies has demonstrated a definite correlation between the SNP C3435T in MDR1 gene and pharmacokinetics of tacrolimus. However, additional studies with large sample size and better study designs are warranted to verify our finding.
背景
已发表的数据显示，MDR1 外显子 26 SNP C3435T 多态性对不同移植后时间的他克莫司药代动力学的影响结果相互矛盾；因此，本研究旨在对不同移植后时间进行荟萃分析，以研究 SNP C3435T 对他克莫司药代动力学的影响。
方法
通过 PUBMED 和 EMBASE 电子资源进行文献检索，检索截至 2011 年的相关文献。提取药代动力学参数，包括剂量给药、浓度和浓度与剂量比，并使用 STATA10.0 进行荟萃分析。
结果
共有 13 篇涉及 1327 人的论文纳入荟萃分析。总体结果表明，SNP C3435T 可影响不同移植后时间的药代动力学参数，CC 基因型患者的浓度剂量比较低，需要更高的他克莫司剂量比 CT 和 TT 基因型。
结论
我们对现有研究的荟萃分析表明，MDR1 基因中的 SNP C3435T 与他克莫司的药代动力学之间存在明确的相关性。然而，需要更多具有较大样本量和更好研究设计的研究来验证我们的发现。
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