Mori Katsuaki, Kikunaga Hiroyuki, Morisue Atsushi, Fujita Koji, Ishikawa Kei-ichi, Sakuragawa Tadayuki, Kumai Koichiro, Miura Hiroshi, Mikami Shuji
Dept. of Surgery, Hino Municipal Hospital.
Gan To Kagaku Ryoho. 2012 Apr;39(4):679-82.
The patient was a 78-year-old woman with a chief complaint of abdominal bloating and constipation who was referred to us and was examined for an AV 12-15 cm, circumferential type 2 rectal cancer. The pathological diagnosis was adenocarcinoma (tub1+tub2). T4 and N2 were suspected based on the CT findings, and because the CEA value was high, the patient was treated with 7 courses of mFOLFOX6 neoadjuvant chemotherapy followed by salvage surgery(low anterior resection+D3). Examination of the surgical specimen revealed chronic inflammatory cell infiltration, including histiocytes accompanied by ulceration, and fibrosis was observed down to SS. No viable cancer cells were detected, and the tumor response was evaluated as a pathological CR. mFOLFOX6 appeared to be effective as neoadjuvant chemotherapy for advanced rectal cancer.
该患者为一名78岁女性，主要症状为腹胀和便秘，转诊至我院后接受检查，发现患有12 - 15厘米的AV、环周型2期直肠癌。病理诊断为腺癌（tub1 + tub2）。根据CT检查结果怀疑为T4和N2期，且由于癌胚抗原（CEA）值较高，该患者接受了7个疗程的mFOLFOX6新辅助化疗，随后进行挽救性手术（低位前切除术 + D3）。手术标本检查显示有慢性炎性细胞浸润，包括伴有溃疡的组织细胞，且观察到直至浆膜下层的纤维化。未检测到存活的癌细胞，肿瘤反应评估为病理完全缓解（CR）。mFOLFOX6作为晚期直肠癌的新辅助化疗似乎有效。
