Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute College of Medicine, University of Florida, Gainesville, FL, USA.
EMBO J. 2012 May 16;31(10):2237-9. doi: 10.1038/emboj.2012.111. Epub 2012 Apr 13.
EMBO J 31 10, 2261–2274 (2012); published online April 13 2012 Chávez-Gutiérrez et al (2012) examine the effects of Alzheimer’s disease (AD) causing presenilin () and amyloid precursor protein () mutations on intramembrane cleavage catalyzed by -secretase. These data provide definitive insights that should settle the long-standing debate regarding the role of loss of function effects of mutations in AD etiology. They also provide additional insights into the complexities of -secretase cleavage that may help to guide future therapeutic discovery efforts not only in AD but in other indications.
EMBO J 31 10, 2261–2274 (2012); published online April 13 2012 Chávez-Gutiérrez 等人（2012 年）研究了阿尔茨海默病（AD）导致早老素（）和淀粉样前体蛋白（）突变对 -分泌酶催化的跨膜切割的影响。这些数据提供了明确的见解，应该解决长期以来关于 AD 病因中 突变失活效应作用的争论。它们还提供了关于 - 分泌酶切割复杂性的更多见解，这可能有助于指导未来的治疗发现工作，不仅在 AD 中，而且在其他适应症中。
