转移关于 γ-分泌酶切割和阿尔茨海默病的复杂争论。
Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease.
机构信息
Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute College of Medicine, University of Florida, Gainesville, FL, USA.
出版信息
EMBO J. 2012 May 16;31(10):2237-9. doi: 10.1038/emboj.2012.111. Epub 2012 Apr 13.
Abstract
EMBO J 31 10, 2261–2274 (2012); published online April 13 2012 Chávez-Gutiérrez et al (2012) examine the effects of Alzheimer’s disease (AD) causing presenilin () and amyloid precursor protein () mutations on intramembrane cleavage catalyzed by -secretase. These data provide definitive insights that should settle the long-standing debate regarding the role of loss of function effects of mutations in AD etiology. They also provide additional insights into the complexities of -secretase cleavage that may help to guide future therapeutic discovery efforts not only in AD but in other indications.
摘要
EMBO J 31 10, 2261–2274 (2012); published online April 13 2012 Chávez-Gutiérrez 等人（2012 年）研究了阿尔茨海默病（AD）导致早老素（）和淀粉样前体蛋白（）突变对 -分泌酶催化的跨膜切割的影响。这些数据提供了明确的见解，应该解决长期以来关于 AD 病因中 突变失活效应作用的争论。它们还提供了关于 - 分泌酶切割复杂性的更多见解，这可能有助于指导未来的治疗发现工作，不仅在 AD 中，而且在其他适应症中。
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