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[大肠杆菌环磷酸腺苷受体蛋白（CRP）与双链胸腺DNA和λpgal DNA的协同非特异性结合]

[Cooperative non-specific binding of the cyclic adenosine 3'--5'-monophosphate receptor protein (CRP) from Escherichia coli to double-stranded thymus and lambda pgal DNA].

作者信息

Blazy B, Takahashi M, Baudras A

出版信息

C R Seances Acad Sci D. 1979 May 7;288(17):1327-30.

PMID:225052
Abstract

Either free or combined with cAMP, CRP binds cooperatively to double-stranded thymus and lambda pgal DNA. The affinity of CRP for both DNAs in these non-specific interactions is increased by cAMP without noticeable change in the degree of cooperativity. Values of the intrinsic association constant, cooperativity parameter, and site size of DNA were determined from ultracentrifugal investigations under near-physiological ionic conditions.

摘要

无论是游离状态还是与环磷酸腺苷（cAMP）结合，环磷酸腺苷受体蛋白（CRP）都会协同结合到双链胸腺DNA和λpgal DNA上。在这些非特异性相互作用中，cAMP会增加CRP与这两种DNA的亲和力，而协同程度没有明显变化。在接近生理离子条件下，通过超速离心研究确定了DNA的内在缔合常数、协同参数和位点大小的值。

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引用本文的文献

1
Non-specific interactions of CRP from E. coli with native and denatured DNAs: control of binding by cAMP and cGMP and by cation concentration.来自大肠杆菌的CRP与天然和变性DNA的非特异性相互作用：cAMP、cGMP以及阳离子浓度对结合的调控
Nucleic Acids Res. 1979 Nov 24;7(6):1699-712. doi: 10.1093/nar/7.6.1699.