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Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):386-92. doi: 10.1107/S1744309112007178. Epub 2012 Mar 27.
3
TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain.
Mol Biol Cell. 2009 Mar;20(5):1565-75. doi: 10.1091/mbc.e08-10-1001. Epub 2009 Jan 14.
4
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
Nat Commun. 2017 Nov 23;8(1):1729. doi: 10.1038/s41467-017-01862-0.
6
Molecular organization of target of rapamycin complex 2.
J Biol Chem. 2005 Sep 2;280(35):30697-704. doi: 10.1074/jbc.M505553200. Epub 2005 Jul 7.

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Small Molecule Modulator of the mTORC2 Pathway Discovered from a DEL Library Designed to Bind to Pleckstrin Homology Domains.
ACS Chem Biol. 2024 Dec 20;19(12):2502-2514. doi: 10.1021/acschembio.4c00597. Epub 2024 Nov 12.
2
gene of unknown function Gohir.A03G007700.1 encodes a potential VAN3-binding protein with a phosphoinositide-binding site.
MicroPubl Biol. 2023 Jan 31;2023. doi: 10.17912/micropub.biology.000669. eCollection 2023.
3
TOR complex 2 is a master regulator of plasma membrane homeostasis.
Biochem J. 2022 Sep 30;479(18):1917-1940. doi: 10.1042/BCJ20220388.
4
Sin1-mediated mTOR signaling in cell growth, metabolism and immune response.
Natl Sci Rev. 2019 Nov;6(6):1149-1162. doi: 10.1093/nsr/nwz171. Epub 2019 Nov 19.
5
RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Proc Natl Acad Sci U S A. 2021 Aug 17;118(33). doi: 10.1073/pnas.2103261118.
7
The 3.2-Å resolution structure of human mTORC2.
Sci Adv. 2020 Nov 6;6(45). doi: 10.1126/sciadv.abc1251. Print 2020 Nov.
8
Architecture of the human mTORC2 core complex.
Elife. 2018 Feb 9;7:e33101. doi: 10.7554/eLife.33101.
9
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
Nat Commun. 2017 Nov 23;8(1):1729. doi: 10.1038/s41467-017-01862-0.
10
PI3K signaling in cancer: beyond AKT.
Curr Opin Cell Biol. 2017 Apr;45:62-71. doi: 10.1016/j.ceb.2017.02.007. Epub 2017 Mar 24.

本文引用的文献

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Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):145-53. doi: 10.1107/S1744309111049761. Epub 2012 Jan 25.
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REFMAC5 for the refinement of macromolecular crystal structures.
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mTOR: from growth signal integration to cancer, diabetes and ageing.
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Molecular replacement with MOLREP.
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Phaser crystallographic software.
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TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain.
Mol Biol Cell. 2009 Mar;20(5):1565-75. doi: 10.1091/mbc.e08-10-1001. Epub 2009 Jan 14.
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Raster3D: photorealistic molecular graphics.
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Regulation of ceramide biosynthesis by TOR complex 2.
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Membrane recognition by phospholipid-binding domains.
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Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.
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