Dong Zhengchao, Liu Feng, Kangarlu Alayar, Peterson Bradley S
Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York State Psychiatric Institute, New York, NY 10032, USA.
Int J Biomed Imaging. 2012;2012:247161. doi: 10.1155/2012/247161. Epub 2012 Feb 20.
Multisection magnetic resonance spectroscopic imaging is a widely used pulse sequence that has distinct advantages over other spectroscopic imaging sequences, such as dynamic shimming, large region-of-interest coverage within slices, and rapid data acquisition. It has limitations, however, in the number of slices that can be acquired in realistic scan times and information loss from spacing between slices. In this paper, we synergize the multi-section spectroscopic imaging pulse sequence with multichannel coil technology to overcome these limitations. These combined techniques now permit elimination of the gaps between slices and acquisition of a larger number of slices to realize the whole brain metabolite mapping without incurring the penalties of longer repetition times (and therefore longer acquisition times) or lower signal-to-noise ratios.
多层面磁共振波谱成像（Multisection magnetic resonance spectroscopic imaging）是一种广泛应用的脉冲序列，与其他波谱成像序列相比具有明显优势，如动态匀场、在层面内较大的感兴趣区覆盖范围以及快速的数据采集。然而，它也存在局限性，即在实际扫描时间内可采集的层面数量以及层面间间距导致的信息丢失。在本文中，我们将多层面波谱成像脉冲序列与多通道线圈技术相结合以克服这些局限性。这些组合技术现在能够消除层面间的间隙并采集更多层面，从而实现全脑代谢物图谱绘制，而不会带来更长重复时间（进而更长采集时间）或更低信噪比的代价。
