Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, CA 90509, USA.
Int J Endocrinol. 2012;2012:625434. doi: 10.1155/2012/625434. Epub 2012 Mar 14.
Hypogonadism in older men is a syndrome characterized by low serum testosterone levels and clinical symptoms often seen in hypogonadal men of younger age. These symptoms include decreased libido, erectile dysfunction, decreased vitality, decreased muscle mass, increased adiposity, depressed mood, osteopenia, and osteoporosis. Hypogonadism is a common disorder in aging men with a significant percentage of men over 60 years of age having serum testosterone levels below the lower limits of young male adults. There are a variety of testosterone formulations available for treatment of hypogonadism. Data from many small studies indicate that testosterone therapy offers several potential benefits to older hypogonadal men. A large multicenter NIH supported double blind, placebo controlled study is ongoing, and this study should greatly enhance the information available on efficacy and side effects of treatment. While safety data is available across many age groups, there are still unresolved concerns associated with testosterone therapy. We have reviewed the diagnostic methods as well as benefits and risks of testosterone replacement therapy for hypogonadism in aging men.
老年男性性腺功能减退症是一种以血清睾酮水平降低和年轻男性性腺功能减退症患者常见的临床症状为特征的综合征。这些症状包括性欲降低、勃起功能障碍、活力下降、肌肉量减少、体脂增加、情绪低落、骨质疏松和骨质疏松症。性腺功能减退症是老年男性的一种常见疾病，超过 60 岁的男性中有相当大的比例血清睾酮水平低于年轻成年男性的下限。有多种睾酮制剂可用于治疗性腺功能减退症。许多小型研究的数据表明，睾酮治疗为老年性腺功能减退症男性提供了一些潜在的益处。一项由美国国立卫生研究院（NIH）支持的大型多中心、双盲、安慰剂对照研究正在进行中，该研究将大大增加关于治疗效果和副作用的可用信息。虽然在许多年龄组中都有安全性数据，但与睾酮治疗相关的仍有一些未解决的问题。我们回顾了诊断方法以及睾酮替代疗法治疗老年男性性腺功能减退症的益处和风险。
