Boegehold M A, Kotchen T A
Department of Medicine, West Virginia University School of Medicine, Morgantown 26506.
Microvasc Res. 1990 Sep;40(2):169-78. doi: 10.1016/0026-2862(90)90016-k.
The purpose of this study was to determine if structural rarefaction of arterioles occurs in the gracilis muscle of Dahl salt-sensitive (DS) rats with salt-induced hypertension. Arteriolar network architecture was studied in cleared muscles removed from DS fed either a high (7% NaCl) or low-normal (0.45% NaCl) salt diet for 4 weeks. Muscles removed from Dahl salt-resistant (DR) rats on high and low-normal salt diets served as controls. The 7% NaCl diet had no effect on arterial pressure in DR, but caused marked hypertension in DS. The density of arcade arterioles was significantly lower in DS than in DR (0.77 vs 1.26 segments/mg tissue, respectively) and was unrelated to either dietary salt content or mean arterial pressure in both strains. The number of transverse arterioles/mm parent vessel was 19% lower in DS on 7% NaCl than in DS on 0.45% NaCl and DR on either diet. These data indicate that compared to normotensive DR, the DS rat with salt-induced hypertension exhibits a lower vascular density within both the arcading and the transverse portions of the gracilis muscle arteriolar network. The lower arcade vessel density reflects an inherent characteristic of the DS strain, whereas the lower transverse arteriole density reflects a true structural rarefaction associated with salt-induced hypertension.
本研究的目的是确定盐诱导高血压的 Dahl 盐敏感（DS）大鼠的股薄肌中是否会出现小动脉结构稀疏。对喂食高盐（7% NaCl）或低正常盐（0.45% NaCl）饮食 4 周的 DS 大鼠所切除的透明肌肉中的小动脉网络结构进行了研究。以喂食高盐和低正常盐饮食的 Dahl 盐抵抗（DR）大鼠所切除的肌肉作为对照。7% NaCl 饮食对 DR 大鼠的动脉血压没有影响，但在 DS 大鼠中导致了明显的高血压。DS 大鼠中小拱小动脉的密度显著低于 DR 大鼠（分别为 0.77 段/毫克组织和 1.26 段/毫克组织），并且与两种品系的饮食盐含量或平均动脉血压均无关。7% NaCl 饮食组的 DS 大鼠每毫米母血管的横向小动脉数量比 0.45% NaCl 饮食组的 DS 大鼠和任一饮食组的 DR 大鼠低 19%。这些数据表明，与血压正常的 DR 大鼠相比，盐诱导高血压的 DS 大鼠在股薄肌小动脉网络的拱状和横向部分均表现出较低的血管密度。较低的拱状血管密度反映了 DS 品系的固有特征，而较低的横向小动脉密度反映了与盐诱导高血压相关的真正结构稀疏。
