Dominici C, Bosman C, De Sanctis S, Clerico A, Thorel M F, Ceccamea A
Istituto di Clinica Pediatrica, Università degli Studi La Sapienza, Roma.
Minerva Pediatr. 1990 Jun;42(6):249-52.
The case of a child affected at birth sacrococcygeal teratoma is reported. Twenty-eight months following surgical resection, the tumor relapsed locally and liver metastases occurred. A biopsy of the sacrococcygeal mass was performed and histologic examination proved it to be an endodermal sinus (yolk sac) tumor. Chemotherapy consisting of etoposide and high-dose carboplatin was started. When a second operation was performed the mass had disappeared and the macroscopically involved areas of liver were removed. Histologic examination demonstrated that the complete necrosis of the tumor was partially replaced by a fibrous scar tissue. The child underwent adjuvant chemotherapy and now is in complete remission fourteen months after the last operation.
报告了一例出生时即患有骶尾部畸胎瘤的儿童病例。手术切除28个月后，肿瘤局部复发并出现肝转移。对骶尾部肿块进行了活检，组织学检查证实为内胚窦（卵黄囊）瘤。开始使用依托泊苷和大剂量卡铂进行化疗。进行第二次手术时，肿块已消失，切除了肝脏肉眼可见受累区域。组织学检查显示肿瘤完全坏死，部分被纤维瘢痕组织取代。该儿童接受了辅助化疗，目前在最后一次手术后14个月处于完全缓解状态。
