特纳综合征和奥尔布赖特遗传性骨营养不良中血浆环磷酸腺苷对甲状旁腺激素的反应。

Plasma cyclic-AMP response to parathyroid hormone in Turner's syndrome and Albright's hereditary osteodystrophy.

作者信息

Ashby J P, Renton W B, MacPherson J N, Price W H, Abbott S R

出版信息

Clin Endocrinol (Oxf). 1979 Jun;10(6):553-6. doi: 10.1111/j.1365-2265.1979.tb02114.x.

DOI:10.1111/j.1365-2265.1979.tb02114.x

Abstract

Purified bovine parathyroid hormone (BPTH) given by injection to five patients with Turner's syndrome, and seven healthy volunteers produced a significant rise in plasma cyclic AMP reacing a maximum within 10 min. In a pseudohypoparathyroid patient there was no increase. Urinary excretion of cyclic AMP exceeded the normal in three out of four patients with Turner's syndrome. Thus, if there is a relationship between Turner's syndrome and Albright's osteodystrophy it is with the incomplete form known as pseudo-pseudohypoparathyroidism.

摘要

给5名特纳综合征患者和7名健康志愿者注射纯化的牛甲状旁腺激素（BPTH）后，血浆环磷酸腺苷（cAMP）显著升高，并在10分钟内达到峰值。而一名假甲状旁腺功能减退患者则无升高。4名特纳综合征患者中有3名的尿环磷酸腺苷排泄量超过正常水平。因此，如果特纳综合征与奥尔布赖特骨营养不良之间存在关联，那也是与被称为假假甲状旁腺功能减退的不完全形式有关。