Studitskiĭ V M, Khrapko K R
Mol Biol (Mosk). 1990 Jul-Aug;24(4):909-19.
A recurrent theme in molecular biology is that of "action at a distance" along DNA. We consider various mechanisms of action of transcriptional enhancers as a well-characterised example of interaction between widely separated DNA-bound proteins. The role of promoter- and enhancer-binding proteins in the formation of a stable promoter complex, and the mechanisms of interaction between multiple activatory DNA sequences is also discussed.
分子生物学中一个反复出现的主题是沿着DNA的“远距离作用”。我们将转录增强子的各种作用机制视为广泛分离的DNA结合蛋白之间相互作用的一个充分表征的例子。还讨论了启动子结合蛋白和增强子结合蛋白在稳定启动子复合物形成中的作用，以及多个激活DNA序列之间的相互作用机制。
