Department of Pediatrics, Navy General Hospital, No. 6 Fucheng Road, Beijing, P.R. China.
Cell Transplant. 2012;21 Suppl 1:S91-8. doi: 10.3727/096368912X633806.
Cerebral palsy (CP) is a chronic nervous system disease that severely damages the physical and developmental health of children. Traditional treatment brings about only improvement of mild to moderate CP, but severe CP still lacks effective interventions. To explore safety and efficacy of using neural progenitor cells (NPCs) to treat CP in children, we performed NPC transplantation in 45 patients with severe CP by injecting NPCs derived from aborted fetal tissue into the lateral ventricle. Gross motor function measures (GMFM), the Peabody Developmental Motor Scale-Fine Motor (PDMS-FM) test, and a unified survey questionnaire designed specifically for children with CP were used to evaluate neurological function of the patients. Motor development was significantly accelerated within the first month after cell transplantation, but the rate of improvement gradually slowed to preoperative levels. However, after 1 year, the developmental level in each functional sphere (gross motor, fine motor, and cognition) of the treatment group was significantly higher compared to the control group. No delayed complications of this therapy were noted. These results suggest that NPC transplantation is a safe and effective therapeutic method for treating children with severe CP.
脑性瘫痪（CP）是一种慢性神经系统疾病，严重损害儿童的身体和发育健康。传统治疗只能改善轻度至中度 CP，但严重 CP 仍然缺乏有效干预。为了探索使用神经祖细胞（NPC）治疗儿童 CP 的安全性和有效性，我们通过将源自流产胎儿组织的 NPC 注射到侧脑室，对 45 名严重 CP 患儿进行 NPC 移植。使用粗大运动功能测量（GMFM）、Peabody 发育运动量表-精细运动（PDMS-FM）测试和专门为 CP 患儿设计的统一调查问卷来评估患者的神经功能。细胞移植后第一个月内运动发育明显加快，但改善速度逐渐减慢至术前水平。然而，1 年后，治疗组在每个功能领域（粗大运动、精细运动和认知）的发育水平明显高于对照组。该治疗方法没有延迟并发症。这些结果表明，NPC 移植是治疗严重 CP 患儿的一种安全有效的治疗方法。
