Department of Rheumatology and Inflammation Research, Institute of Medicine, Guldhedsgatan 10A, Gothenburg, S-413 46, Sweden.
Arthritis Res Ther. 2012 Apr 16;14(2):R76. doi: 10.1186/ar3799.
Staphylococcus aureus is a common cause of bacterial arthritis, which is associated with progressive bone loss in affected joints. We recently showed that S. aureus infection also induces a significant systemic bone loss in mice. This study was performed to assess the effect of estradiol treatment on the clinical course and outcome of S. aureus arthritis and on infection-induced bone loss in experimental S. aureus infection.
Mice were ovariectomized, treated with estradiol or placebo, and S. aureus infection was established by intravenous inoculation of bacteria.
Estradiol treatment was found to decrease significantly the frequency and clinical severity of S. aureus arthritis, a finding that was accompanied with significantly higher serum levels of interleukin-10 in estradiol-treated mice. Estradiol was also highly protective against S. aureus-induced systemic trabecular, and cortical bone loss. Lack of endogenous estrogens and S. aureus infection had additive effects on trabecular bone loss. The S. aureus-infected, ovariectomized mice lost as much as 76% of their trabecular bone mass.
Treatment with estradiol ameliorates S. aureus arthritis and is protective against infection-induced systemic bone loss in experimental S. aureus infection.
金黄色葡萄球菌是细菌性关节炎的常见病因，与受累关节的进行性骨丢失有关。我们最近发现金黄色葡萄球菌感染也会导致小鼠发生明显的系统性骨丢失。本研究旨在评估雌二醇治疗对金黄色葡萄球菌性关节炎的临床病程和结局以及对实验性金黄色葡萄球菌感染中感染诱导的骨丢失的影响。
小鼠行卵巢切除术，用雌二醇或安慰剂治疗，并通过静脉接种细菌建立金黄色葡萄球菌感染。
发现雌二醇治疗可显著降低金黄色葡萄球菌性关节炎的频率和临床严重程度，这一发现伴随着雌二醇治疗小鼠血清白细胞介素-10水平显著升高。雌二醇对金黄色葡萄球菌诱导的全身小梁骨和皮质骨丢失也有高度保护作用。内源性雌激素缺乏和金黄色葡萄球菌感染对小梁骨丢失有相加作用。金黄色葡萄球菌感染的去卵巢小鼠失去了多达 76%的小梁骨量。
雌二醇治疗可改善金黄色葡萄球菌性关节炎，并对实验性金黄色葡萄球菌感染中感染诱导的系统性骨丢失具有保护作用。
