Department of Food and Nutrition, Hanyang University, Seoul, South Korea.
Ann Nutr Metab. 2012;60(2):146-53. doi: 10.1159/000337302. Epub 2012 Apr 14.
Osteoporosis, a major health problem among postmenopausal women, is influenced by dietary factors. The purpose of the present study was to evaluate the hypothesis that erythrocyte levels of n-3 polyunsaturated fatty acid (PUFA) and the dietary intake of fish are associated with risk of osteoporosis and correlate with bone mass in postmenopausal Korean women with the disease.
Fifty cases and 100 controls were recruited. Osteoporosis was defined according to the International Society for Clinical Densitometry guideline as a score lower than -2.5 SD below the T-score for lumbar vertebrae L₁-L₄, femoral neck or femoral total.
The T-score of the femoral neck was positively correlated with erythrocyte levels of n-3 PUFA, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the intake of fish, and was negatively correlated with the ratio of n-6/n-3 PUFA after adjusting for age, years after menopause and height. In addition, the risk of osteoporosis was positively associated with erythrocyte levels of saturated fatty acids but negatively associated with EPA + DHA.
Erythrocyte levels of n-3 PUFA and the intake of fish were positively correlated with bone mass. In particular, erythrocyte levels of EPA + DHA reduced the risk of osteoporosis in postmenopausal Korean women.
骨质疏松症是绝经后妇女的主要健康问题之一，受饮食因素影响。本研究旨在验证以下假设：红细胞中 n-3 多不饱和脂肪酸（PUFA）水平和鱼类的饮食摄入量与骨质疏松症风险相关，并与患有该疾病的绝经后韩国女性的骨量相关。
招募了 50 例病例和 100 例对照。骨质疏松症根据国际临床密度测定协会的指南定义为腰椎 L₁-L₄、股骨颈或股骨总 T 评分低于 -2.5 SD 的评分。
股骨颈 T 评分与红细胞 n-3 PUFA、二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）和鱼类摄入量呈正相关，与年龄、绝经后年限和身高调整后的 n-6/n-3 PUFA 比值呈负相关。此外，骨质疏松症的风险与红细胞饱和脂肪酸水平呈正相关，与 EPA+DHA 呈负相关。
红细胞 n-3 PUFA 水平和鱼类摄入量与骨量呈正相关。特别是，红细胞 EPA+DHA 水平降低了绝经后韩国女性骨质疏松症的风险。
