手性选择性全合成炔烃类类胡萝卜素别叶黄素和三叶黄素。
Stereoselective total synthesis of the acetylenic carotenoids alloxanthin and triophaxanthin.
机构信息
Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
出版信息
Org Biomol Chem. 2012 May 28;10(20):4103-8. doi: 10.1039/c2ob25321f. Epub 2012 Apr 17.
PMID:22508221
Abstract
Stereoselective total synthesis of the C(40)-diacetylenic carotenoid alloxanthin (1) and the C(31)-acetylenic apocarotenoid triophaxanthin (2) was accomplished by Wittig condensation of C(10)-dialdehyde 20 or C(16)-keto aldehyde 19, respectively, with C(15)-acetylenic tri-n-butylphosphonium salt 12.
摘要
通过 C(10)-二醛 20 或 C(16)-酮醛 19 与 C(15)-炔基三丁基膦盐 12 的 Wittig 缩合反应，分别完成了 C(40)-二乙酰基类胡萝卜素 alloxanthin (1) 和 C(31)-炔基类胡萝卜素 apocarotenoid triophaxanthin (2) 的立体选择性全合成。
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