Department of Applied Physics, Aalto University, 6 Aalto University, Finland.
Small. 2012 Jul 9;8(13):2016-20. doi: 10.1002/smll.201102697. Epub 2012 Apr 17.
Degradable Newkome-type and polylysine dendrons functionalized with spermine surface units are used to control the formation of DNA origami structures. The intact dendrons form polyelectrolyte complexes with the scaffold strands, therefore blocking the origami formation. Degradation of the dendron with an optical trigger or chemical reduction leads to the release of the DNA scaffold and efficient formation of the desired origami structure. These results provide new insights towards realizing responsive materials with DNA origami.
具有 spermine 表面单元的可降解 Newkome 型和聚赖氨酸树枝状分子被用于控制 DNA 折纸结构的形成。完整的树枝状分子与支架链形成聚电解质复合物，从而阻止折纸的形成。用光触发或化学还原降解树枝状分子会导致 DNA 支架的释放，并有效地形成所需的折纸结构。这些结果为实现具有 DNA 折纸结构的响应性材料提供了新的见解。
