Communicable Diseases Centre, Tan Tock Seng Hospital, Singapore.
Singapore Med J. 2012 Apr;53(4):223-9; quiz 230.
With our rapidly ageing population and advancing treatments for patients with haematological, oncologic and rheumatological diseases, there are increasing numbers of immunocompromised patients presenting to primary care and general hospitals with opportunistic infections. This review considers the trends of these infections across four representative subgroups: fungal infections following haematopoietic stem cell transplant; viral infections post solid organ transplant; mycobacterial infections during treatment with targeted biological agents; and bacterial infections as a cause of fever in neutropenia. We also consider the impact of host, pathogens, environments and treatments on the epidemiology and outcomes of these infections.
随着人口老龄化的加速和血液病、肿瘤学和风湿病患者治疗水平的提高，越来越多的免疫功能低下患者因机会性感染而到基层医疗机构和综合医院就诊。本综述考虑了以下四个具有代表性的亚组中这些感染的趋势：造血干细胞移植后真菌感染；实体器官移植后病毒感染；靶向生物制剂治疗期间分枝杆菌感染；中性粒细胞减少症发热的细菌感染。我们还考虑了宿主、病原体、环境和治疗对这些感染的流行病学和结果的影响。
