药物相互作用转化研究的必要性。
The need for translational research on drug-drug interactions.
机构信息
Center for Clinical Epidemiology, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Clin Pharmacol Ther. 2012 May;91(5):771-3. doi: 10.1038/clpt.2012.39.
Abstract
Drug-drug interactions (DDIs) are an important clinical and public health concern. Although DDI screening now occurs during drug development, it is difficult to predict clinical importance based on in vitro experiments. Furthermore, older drugs that were not screened may have interactions that have not yet been identified. In this Commentary, we review the importance of DDIs and argue that a translational research approach is needed to produce clinically actionable information as well as generalizable biological knowledge.
摘要
药物-药物相互作用（DDIs）是一个重要的临床和公共卫生问题。虽然现在在药物开发过程中进行了 DDI 筛选，但基于体外实验很难预测其临床重要性。此外，以前未经过筛选的老药物可能存在尚未发现的相互作用。在这篇评论中，我们回顾了 DDIs 的重要性，并认为需要采用转化研究方法来提供具有临床可操作性的信息以及可推广的生物学知识。
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