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[D-Pen2, D-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice.

作者信息

Murray C W, Cowan A

机构信息

Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140.

出版信息

Psychopharmacology (Berl). 1990;102(3):425-6. doi: 10.1007/BF02244117.

DOI:10.1007/BF02244117
PMID:2251341
Abstract

[D-Pen2, D-Pen5]enkephalin (DPDPE; 3-30 micrograms) and morphine (10 micrograms) both caused Straub tails, increased locomotion, and circling after ICV administration to ICR mice. DPDPE-induced tail stiffening was reduced when mice were pretreated with naloxone (0.5 mg/kg SC) or beta-funaltrexamine (10 micrograms ICV), but not with ICI 174864 (2 mg/kg SC), the selective antagonist at delta opioid receptors. These results point to (a) mu receptors mediating the tail stiffening and (b) the loss of delta receptor selectivity after 10 and 30 micrograms DPDPE.

摘要

相似文献

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本文引用的文献

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The anatomical basis of the straub phenomenon.施特劳布现象的解剖学基础。
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Br J Pharmacol. 1985 Apr;84(4):927-32. doi: 10.1111/j.1476-5381.1985.tb17387.x.
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In vivo studies on delta opioid receptors.δ阿片受体的体内研究。
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