Dissolution of urinary stones by calcium-chelating agents: A study using a model system.

Pellets made by dispersing microcrystals of calcium oxalate monohydrate throughout an organic matrix have served as models for kidney stones in studies of factors governing their dissolution by calcium-chelating agents. These factors include pH, ionic strength, concentration of chelating agent, and addition of other acids and bases. The method shows good reproducibility. Results have been applied to improving a clinical procedure for kidney stone dissolution.