初乳与血清中的免疫球蛋白A（IgA）之间的相关性比唾液免疫球蛋白A与总免疫球蛋白A之间的相关性更密切。

[Correlation between IGA from colostrum and serum and IGA is closer than between salivary IGA and total IGA].

作者信息

Tallería Orriols J J, Blanco Quirós A, Gómez Carrasco J A, Díez Fernández T, Garrido M

机构信息

Cátedra de Pediatría, Facultad de Medicina de Valladolid.

出版信息

An Esp Pediatr. 1990 Jul;33(1):31-5.

PMID:2252283

Abstract

Colostrum, serum and saliva were simultaneously obtained from 50 normal mothers. 19-45 years old, 36-72 hours post-delivery. Total IgA level and class-IgA antibodies against 3 common food antigens (lactoglobulin, gliadin and ovalbumin) and 4 types of salmonella (typhi, paratyphi A, B and C) were determined in all samples. The 7 antibodies (Ab) were detected in colostrum, by ELISA, in a higher percentage of samples (88-62%), than in serum (82-34%) and saliva (77-27%). These percentages were higher for food-Ab than for anti-salmonella Ab. The total colostral IgA was close correlated with food-Ab in colostrum (p less than 0.001) and quite poorer with anti-salmonella Ab (p less than 0.05-p less than 0.01). A good correlation was generally also present between Ab from colostrum/serum, but was worse between both secretions (colostrum/saliva). The present results suggest that colostrum specific Ab levels can be predicted, depending on total IgA and the specific Ab from serum.

摘要

从50名年龄在19至45岁、产后36至72小时的正常母亲身上同时采集初乳、血清和唾液。测定所有样本中的总IgA水平以及针对3种常见食物抗原（乳球蛋白、麦醇溶蛋白和卵清蛋白）和4种沙门氏菌（伤寒沙门氏菌、甲型副伤寒沙门氏菌、乙型副伤寒沙门氏菌和丙型副伤寒沙门氏菌）的IgA类抗体。通过ELISA检测，初乳中7种抗体（Ab）在样本中的检出率（88% - 62%）高于血清（82% - 34%）和唾液（77% - 27%）。食物抗体的检出率高于抗沙门氏菌抗体。初乳中的总IgA与初乳中的食物抗体密切相关（p小于0.001），与抗沙门氏菌抗体的相关性则较差（p小于0.05 - p小于0.01）。初乳/血清中的抗体之间通常也存在良好的相关性，但两种分泌物（初乳/唾液）之间的相关性较差。目前的结果表明，初乳特异性抗体水平可以根据总IgA和血清中的特异性抗体来预测。