Immunology and Parasitology, Department of Microbiology, College of Health Sciences, Mekelle University, Ethiopia.
Clin Infect Dis. 2012 Jul;55(1):91-102. doi: 10.1093/cid/cis395. Epub 2012 Apr 20.
Group B Streptococcus (GBS) is a leading cause of neonatal sepsis in developed countries. Its burden in the developing world is less clear. Studies reporting neonatal GBS disease incidence from developing countries were identified from 5 literature databases. Studies were assessed with respect to case finding and culture methods. Only 20 studies were identified. The GBS incidence ranged 0-3.06 per 1000 live births with variation within and between geographic regions. All but 1 study identified GBS cases within a hospital setting, despite the potential for births in the community. Possible case under-ascertainment was only discussed in 2 studies. A higher GBS incidence was reported when using automated culture methods. Prospective, population-based surveillance is urgently needed in developing countries to provide an accurate assessment of the neonatal GBS disease burden. This will be crucial for the design of interventions, including novel vaccines, and the understanding of their potential to impact mortality from neonatal sepsis.
B 群链球菌（GBS）是发达国家新生儿败血症的主要病因。其在发展中国家的负担不太明确。从 5 个文献数据库中确定了报告发展中国家新生儿 GBS 疾病发病率的研究。研究评估了病例发现和培养方法。仅确定了 20 项研究。GBS 的发病率范围为每 1000 例活产儿 0-3.06 例，地域内和地域间存在差异。尽管存在社区分娩的可能性，但除了 1 项研究外，所有研究都在医院环境中确定了 GBS 病例。只有 2 项研究讨论了可能存在的病例漏诊情况。使用自动化培养方法时，报告的 GBS 发病率更高。发展中国家迫切需要进行前瞻性、基于人群的监测，以准确评估新生儿 GBS 疾病负担。这对于干预措施的设计至关重要，包括新型疫苗，并了解它们对降低新生儿败血症死亡率的潜力。
