Lardennois B, Vazeux H, Menu G, Visseaux B, Ploton D, Adnet J J
Service d'Urologie, CHU Reims.
Ann Urol (Paris). 1990;24(5):400-7.
The authors present a preliminary series if two groups of ten patients with advanced prostatic cancer with sufficient follow-up in whom the study of nucleolar organizers (NOR) was performed according to a new light microscopy argentaffin technique. This original technique was developed by D. Ploton at the CHU de Reims. The principles of the technique are presented. The interpretation of the results, very dispersed at the present time, leads the authors two us two new clinical and histological indicators estimating the degree of severity of the prostatic cancer: the index of clinical severity based on the quality of survival and its duration from time T0 and the multifactorial index of histological severity based on the WHO classification, Gleason grade and NOR.
作者报告了两组各10例晚期前列腺癌患者的初步系列研究，这些患者有足够的随访时间，并根据一种新的光学显微镜嗜银技术对核仁组织者（NOR）进行了研究。这项原创技术是由兰斯大学中心医院的D. 普罗东开发的。文中介绍了该技术的原理。目前结果非常分散，这使作者得出了两个用于评估前列腺癌严重程度的新的临床和组织学指标：基于生存质量及其从T0时间开始的持续时间的临床严重程度指数，以及基于世界卫生组织分类、 Gleason分级和NOR的组织学严重程度多因素指数。
