新生儿柠檬酸杆菌脑脓肿：早期手术干预及文献综述
Citrobacter brain abscesses in neonates: early surgical intervention and review of the literature.
作者信息
Chowdhry Shakeel A, Cohen Alan R
机构信息
Rainbow Babies & Children's Hospital, The Neurological Institute, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
出版信息
Childs Nerv Syst. 2012 Oct;28(10):1715-22. doi: 10.1007/s00381-012-1746-4. Epub 2012 Apr 15.
PURPOSE
Citrobacter koseri, a facultatively anaerobic, lactose-fermenting, gram-negative bacilli, has a strong propensity to form cerebral abscesses. C. koseri brain abscesses can be a devastating disease of infancy and childhood with more than 30% succumbing to the disease and more than 50% suffering severe neurological deficits.
METHODS
This study represents a retrospective review of two cases of C. koseri brain abscesses along with a review of the literature regarding diagnosis and treatment.
RESULTS
Early aggressive surgical and medical treatment resulted in favorable outcomes for two children with C. koseri brain abscesses, one diagnosed at 6 weeks of age and the other at 2 months of age.
CONCLUSION
C. koseri brain abscesses can be devastating and have been associated historically with significant morbidity and mortality. However, favorable outcomes are possible, and aggressive surgical and medical management should be considered for patients with C. koseri abscesses.
目的
科氏柠檬酸杆菌是一种兼性厌氧、乳糖发酵的革兰氏阴性杆菌，极易形成脑脓肿。科氏柠檬酸杆菌脑脓肿可能是婴幼儿期的一种毁灭性疾病，超过30%的患者会死于该病，超过50%的患者会出现严重神经功能缺损。
方法
本研究对两例科氏柠檬酸杆菌脑脓肿病例进行回顾性分析，并对相关诊断和治疗的文献进行综述。
结果
早期积极的手术和药物治疗使两名患有科氏柠檬酸杆菌脑脓肿的儿童获得了良好的治疗效果，其中一名在6周龄时被诊断出，另一名在2月龄时被诊断出。
结论
科氏柠檬酸杆菌脑脓肿可能具有毁灭性，历史上一直与高发病率和死亡率相关。然而，良好的治疗效果是可能的，对于患有科氏柠檬酸杆菌脓肿的患者，应考虑积极的手术和药物治疗。
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