Gaemperli Oliver, Kaufmann Philipp A
Kardiovaskuläres Zentrum, Abteilung Herzbildgebung, Universitätsspital Zürich, Rämistrasse 100, Zürich, Switzerland.
Clin Res Cardiol Suppl. 2011 May;6:32-42. doi: 10.1007/s11789-011-0024-4.
CT coronary angiography and myocardial perfusion scintigraphy are both established noninvasive techniques for the diagnosis of coronary artery disease (CAD). Cardiac hybrid imaging consists of the combination (or fusion) of both modalities and allows obtaining complementary morphological (coronary anatomy, stenoses) and functional (myocardial perfusion) information in a single image. The increased availability of these techniques in clinical practice has also raised a controversy with regard to which patients should undergo such integrated examinations. The feasibility and clinical value of hybrid imaging has been documented in small cohort studies and selected series of patients. The incremental value of the hybrid technique arises from the spatial co-registration of perfusion defects with coronary stenoses. This allows an assessment of the hemodynamic relevance of coronary stenoses and the determination of the need for revascularization procedures in each individual artery. Thus, it can be anticipated that the ongoing efforts to reduce radiation exposure and the increasing clinical interest will further pave the way for an ever-increasing use of cardiac hybrid imaging in clinical practice.
CT冠状动脉造影和心肌灌注闪烁扫描术都是诊断冠状动脉疾病(CAD)的成熟无创技术。心脏混合成像由这两种模式的结合(或融合)组成,能够在单一图像中获取互补的形态学(冠状动脉解剖结构、狭窄情况)和功能学(心肌灌注)信息。这些技术在临床实践中可用性的提高也引发了关于哪些患者应接受此类综合检查的争议。混合成像的可行性和临床价值已在小型队列研究和特定患者系列中得到证实。混合技术的增量价值源于灌注缺损与冠状动脉狭窄的空间共配准。这使得能够评估冠状动脉狭窄的血流动力学相关性,并确定每条动脉是否需要进行血运重建手术。因此,可以预期,当前在减少辐射暴露方面所做的努力以及日益增长的临床兴趣将进一步为心脏混合成像在临床实践中的更多应用铺平道路。