NANOG 和 KLF4 对乳腺癌的预后意义。
Prognostic significance of NANOG and KLF4 for breast cancer.
机构信息
Department of Surgery and Science, Graduate School of Research Into Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama, Japan,
出版信息
Breast Cancer. 2014 Jan;21(1):96-101. doi: 10.1007/s12282-012-0357-y. Epub 2012 Apr 17.
BACKGROUND
Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.
METHODS
In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.
RESULTS
Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014).
CONCLUSIONS
Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.
背景
一些诱导多能干细胞（iPS 细胞）诱导因子已被报道在乳腺癌中表达。本研究旨在探讨 iPS 细胞诱导因子的表达与乳腺癌患者预后的关系。
方法
采用组织微阵列分析，用免疫组织化学法检测 100 例乳腺癌患者中 c-MYC、KLF4、NANOG、OCT4 和 SOX2 的表达。
结果
NANOG 强表达的患者无病生存率（DFS）和总生存率明显低于 NANOG 弱表达的患者（P=0.004 和 0.033）。相反，KLF4 强表达的患者 DFS 较好（P=0.014）。
结论
NANOG 强表达是乳腺癌患者预后不良的指标，而 KLF4 是预后良好的指标。我们的结果表明，NANOG 刺激乳腺癌细胞的生长和转移，而 KLF4 抑制这些过程。
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