Sakamoto Sachiko, Oiso Naoki, Emoto Masakatsu, Uchida Shusuke, Hirao Ayaka, Tatsumi Yoichi, Matsumura Itaru, Kawada Akira
Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
Case Rep Dermatol. 2012 Jan;4(1):47-9. doi: 10.1159/000337195. Epub 2012 Mar 1.
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression. Acute promyelocytic leukemia (acute myeloid leukemia M3) is caused by translocation of reciprocal chromosomal rearrangement t(15;17), which produces an oncogenic protein. We herein describe a 71-year-old man having cellulitis with leukocytopenia as a first sign of acute promyelocytic leukemia. Dermatologists and hematologists should keep in mind that patients with a hematologic malignancy, such as acute promyelocytic leukemia, can develop cellulitis with leukocytopenia.
血液系统恶性肿瘤患者存在免疫抑制，可能会出现皮肤或侵袭性感染，作为免疫抑制的首要体征。急性早幼粒细胞白血病（急性髓系白血病M3型）由相互染色体易位t(15;17)引起，该易位产生一种致癌蛋白。我们在此描述一名71岁男性，其蜂窝织炎伴白细胞减少是急性早幼粒细胞白血病的首发体征。皮肤科医生和血液科医生应牢记，血液系统恶性肿瘤患者，如急性早幼粒细胞白血病患者，可能会出现伴白细胞减少的蜂窝织炎。
