纤维蛋白原与小鼠黑色素瘤细胞的相互作用：与细胞膜的共价结合及对淋巴因子激活的杀伤细胞识别的保护作用。
Interaction of fibrinogen with murine melanoma cells: covalent association with cell membranes and protection against recognition by lymphokine-activated killer cells.
作者信息
Cardinali M, Uchino R, Chung S I
机构信息
Laboratory of Cellular Development and Oncology, National Institute of Dental Research, NIH, Bethesda, Maryland 20892.
出版信息
Cancer Res. 1990 Dec 15;50(24):8010-6.
PMID:2253243
Abstract
B16/F10 melanoma cells, in a medium containing fibrinogen, form a coating of fibrin(ogen) on their surfaces. This coating is cross-linked in a manner characteristic of catalysis by cellular transglutaminase. The fibrin(ogen) coating on the surface of these tumor cells provides protection against the lytic effect of autologous lymphokine-activated killer cells.
摘要
B16/F10黑色素瘤细胞在含有纤维蛋白原的培养基中，其表面会形成一层纤维蛋白（原）涂层。这种涂层以细胞转谷氨酰胺酶催化的典型方式发生交联。这些肿瘤细胞表面的纤维蛋白（原）涂层可保护细胞免受自体淋巴因子激活的杀伤细胞的裂解作用。
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